Alzheimer’s disease (AD) is a neurodegenerative disorder that affects the superior capabilities of the nervous system, severely altering learning and memory. It is the fourth leading cause of death in the world and it is estimated that around 18 million people live with this disease without a treatment that could revert the associated damage. In 2000, Dr. Nibaldo Inestrosa published that the loss of Wnt signaling is involved in the pathogenic mechanism of AD. In the Molecular Neurobiology Laboratory, scientists investigate the interactions of components from the canonical (Wnt/β-catenin) and non-canonical (JNK and calcium) Wnt pathways with central synaptic elements present in the synaptic cleft and the dendritic spine. Concurrently, they study synthetic derivatives of hyperforin, which break up Ab fibers. Using animal models of AD this research group has shown that hyperforin improves spatial memory by reducing total amyloid plaques, and inflammatory and oxidative damage.

Investigator in charge: Nibaldo Inestrosa