Miguel Bronfman

Investigación

Peroxisomal proliferator activated receptors (PPARs) transcription factors in neurodegenerative disorders

PPARs (α, β/δ and γ isoforms) function as metabolic sensors that control and drive the adaptation of cells to pathophysiological changes and to oxidative stress insult associated with chronic pathologies. They do so by sensing intracellular levels of low concentration lipid metabolites which act as ligands and activators of PPARs, and whose concentration might determine cell fate and survival. We are interested in the role of PPARs in neuronal and glial function, as well as in pathogenic conditions such as neurodegenerative disorders (Alzheimer's and demyelinating progression) and glial cell transformation (gliomas).

Objetivs:

• Role of PPARs in neuronal and oligodendroglial cells
• Chilean algae as a natural source of PPARs agonist