Authors of the Outreach book "The Weight of Obesity in the 21st Century" at radio program Foro Ciudadano

Alfonso Gonzalez

Investigación

Cancer: Proteins Traffic and Disease

The normal cell's transformation into a malignant cell frequently involves a dysfunction of the Epidermal Growth Factor Receptor (EGFR). The results of new antitumoral drugs suggest that it would be very promissory to have a complement of medicines directed against this receptor as anti-cancer target. Studying the endocytic route EGFR movement we have found new strategies to interfere with it's function in a complementary way to other drugs. We are applying this knowledge to study gliomas, one of the most aggressive human cancers.

Objetivs:

  • Molecular mechanisms of vesicular protein trafficking
  • Endocytic control of cell surface EGFR availability as a new anti-tumoral target
  • Neurotoxicity of autoantibodies associated with neuropsychiatric lupus 
Referencias Seleccionadas
Autor(es) Título Fecha
Gravotta D, Deora A, Perret E, Oyanadel C, Soza A, Schreiner R, Gonzalez A, Rodriguez-Boulan E. AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1564-9 0
Donoso M., Cancino J., Lee J., van Kerhof P., Retamal C., Bu G., González A., Cáceres A., Marzolo M.P “Polarized traffic of LRP1 involves AP1B and SNX17 operating upon Y-dependent sorting motifs in different pathways”. Mol Biol Cell nov-19. 2008 0
Massardo L., Metz C., Evelin P., Mezzano V., Jarpa E., Babul M., Guzmán, A.M., Sabine, A., Kaltnerf H., Gabius H.J., González A., Soza, A “Autoantibodies agains galectin-8: Their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute immflamation Lu 0
Matus S, Burgos PV, Bravo-Zehnder M, Kraft R, Porras OH, Farías P, Barros LF, Torrealba F, Massardo L, Jacobelli, González A. Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis. J Exp Med. 2007 Dec 24;204 (13):3221-34. 0
Cancino J, Torrealba C, Soza A, Yuseff MI, Gravotta D, Henklein P, Rodriguez-Boulan E, González A. Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell. 2007 Dec;18(12):4872-84. 0

Academic CV

Contact Alfonso Gonzalez

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Pontificia Universidad Católica