Authors of the Outreach book "The Weight of Obesity in the 21st Century" at radio program Foro Ciudadano

Nibaldo C. Inestrosa

InvestigaciĂłn

Alzheimer´s disease: from synaptic protection to treatment

Alzheimer disease (AD) is a progressive neurodegenerative disorder in which age is the most important risk factor. AD brain is characterized by both extracellular (amyloid plaques) and intracellular aggregates (neurofibrillary tangles). Amyloid aggregates, formed by the amyloid-β-peptide (Aβ), trigger the first pathological events observed in the disease. Other events include, oxidative stress, inflammatory reactions, and alterations in intracellular signaling including the Wnt pathway. Present anti-AD drugs, based on inhibitors of cholinesterase and antagonists of glutamate receptors, can retard some progress of the disease but in less than a half of the cases. There is no treatment to revert the disease.

Objectivs:

  • Wnt signaling and synaptic function
  • Neuroprotection against amyloid-promoting damage at the synaptic level
  •  Use of dual-AChE inhibitors with anti-Alzheimer's potential
  • Search for natural products with anti- Alzheimer´s properties
Referencias Seleccionadas
Autor(es) Título Fecha
Inestrosa NC, Dinamarca MC, Alvarez A. Amyloid-cholinesterase interactions. Implications for Alzheimer’s disease. FEBS J. 2008 Feb;275(4):625-32. Review. 0
Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC. Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway. Neurodegener Dis. 2008;5(3-4):149-52. 0
Cerpa W, Dinamarca MC, Inestrosa NC. Structure-function implications in Alzheimer’s disease: effect of Abeta oligomers at central synapses. Curr Alzheimer Res. 2008 Jun;5(3):233-43. 0
Colombres M, HenrĂ­quez JP, Reig GF, Scheu J, CalderĂłn R, Alvarez A, Brandan E, Inestrosa NC. Heparin activates Wnt signaling for neuronal morphogenesis. J Cell Physiol. 2008 Sep;216(3):805-15. 0
Cerpa W, Godoy JA, Alfaro I, Farías G, Metcalfe MJ, Fuentealba R, Bonansco C and Inestrosa NC. “Wnt - 7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons” J. BIOL. CHEM 283 / 5918-5927. 2008 0
Inestrosa N.C., Dinamarca, M. and Alvarez, A Amyloid-Cholinesterase interactions: Implications for Alzheimer´s Disease. FEBS JOURNAL 275 / 625 – 632. 2008 0
Dinamarca MD, Colombres M, Cerpa W, Bonansco C and Inestrosa. Beta-Amyloid Oligomers Affect the Structure and Function of the Postsynaptic Region: Role of the Wnt Signaling Pathway NEURODEGEN. DIS 5 / 149 – 152. 2008 0
Rebolledo D, Minniti A, Grez P, Fadic R, Kohn R. and Inestrosa NC Inclusion Body Myositis: A View from the Caenorhabditis elegans Muscle MOL. NEUROBIOL 38 / 178 – 198. 2008 0
Inestrosa NC and Toledo E “The Role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease”. MOL. NEURODEGENER 24 / 3-9. 2008 0
Simonetta S, Romanowski A, Minniti A, Inestrosa NC and Golombek D “Circadian stress tolerance in adult Caenorhabditis elegans”. J. COMP. PHYSIOL. A NEUROTHOL SENS NEURAL BEHAV. PHYSIOL 194 / 821-828. 2008 0
Dinamarca M, Arrázola M, Toledo E, Cerpa W, Hancke J and Inestrosa NC “Release of Acetylcholinesterase (AChE) from β-Amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice”. CHEM.BIOL. INTERACT 175 / 142-149. 2 0
Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa NC and Alvarez A “STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits”. BRAIN 131 / 2425-2442. 2008 0
Chacón MA, Varela-Nallar L and Inestrosa NC “Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers”. J. CELL PHYSIOL 217 / 215-227. 2008 0
Enrique M. Toledo, Marcela Colombres, Nibaldo C. Inestrosa “Wnt signaling in neuroprotection and stem cell differentiation”. Progress in Neurobiology 86 / 281-296. 2008 0
Colombres M, Henríquez JP, Reig G, Scheu J, Calderón R, Alvarez A., Brandan E and Inestrosa N.C “Heparin Activates Wnt Signaling for Neuronal Morphogenesis”. J. CELL.. PHYSIOL 216 / 805-815. 2008 0

Academic CV

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