Enrique Brandan

Biological Sciences, Universidad de Chile (1979)
PhD, Cell and Molecular Biology, PUC (1985)
Postdoctoral Fellow, University of Massachussetts, USA (1988)

Full Professor
Faculty of Biological Sciences
Pontificia Universidad Católica de Chile
Phone: (56-2) 223542725
Email: ebrandan@bio.puc.cl

Research Interests:

• Connective tissue growth factor (CTGF/CCN2) and its relationship with fibrosis and hypoxia in denervation and neuromuscular diseases.

• Using inhibitors of NFKB in muscular dystrophy animal models.

• Study of the alternative Ang-1-7/ACE2/MAS axis in the modulation of fibrosis and reparation of skeletal muscle tissue.

Objetives:

• Search for protein derived inhibitors of TGF-b and CTGF, two strong fibrotic agents.

• Study the role of CTGF in skeletal muscular fibrosis by approaches of loss or gain of function of CTGF

• Use the antibodies against CTGF and their effect on skeletal muscular fibrosis.

• Determine the role of the Renin-Angiotensin-System on skeletal muscular fibrosis.

• Use of botanical drug to inhibit skeletal muscular fibrosis and determine their effect on skeletal muscular function.

• Determine the extent of cell therapy under different fibrotic conditions to correct dystrophin deficiency in DMD.

Publications: