The Biomedical Cytology Laboratory is mainly dedicated to two research lines: 1) Protein trafficking in cell polarity and cancer, where the interrelationship between endocytic recycling and the secretory pathway is emphasized, both in the polarized apical/basolateral phenotype of epithelial cells and their alterations, and potential therapeutics in cancer. An important aspect has been the discovery of a signaling pathway that regulates the endocytic trafficking of the epidermal growth factor receptor (EGFR), which can be pharmacologically perturbed with anti-tumoral consequences, and can therefore be used as a new strategy for treating cancer; 2) Autoantibodies and neuronal dysfunction in the brain. Here, the focus is on the normal and pathogenic function of a new protein located at the neuronal cell surface. This protein was discovered in this laboratory as a target of an autoantibody associated with psychosis and cognitive deficits in systemic lupus erythematosus, a prototype autoimmune disease.
Laboratory Head: Dr. Alfonso González